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KMID : 0370220070510010068
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Yakhak Hoeji
2007 Volume.51 No. 1 p.68 ~ p.74
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Antigastritic and Anti Helicobacter pylori Effects of Baicalein from Scutellaria Baicalensis
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Kang Min-Hee
Lee Jung-Hun
Lee Yong-Soo
Son Kun-Ho
Lee Dong-Hwa
Kim Yeong-Shik
Kang Sam-Sik
Bang Hyo-Choon
Jeong Choon-Sik
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Abstract
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Scutellaria Radix, the dried roots of Scutellaria baicalensis Georgi (Labiatae). has been used in oriental traditional medicine for treatment of fever, urine disorder, diarrhea, inflammation. Present study was carried out for the gastroprotective effect of chrysin, baicalcin, baicalin, wogonin wogonin from Scutellaria baicalensis. This reports evaluated antioxidant effect, antibacterial activity against Helicobacter pylori and HCl·ethanol-induced gastric lesion in rats and showed the significant effectiveness. It may be regarded that the antigastritic effects and antibacterial activity of baicalin, baicalein from scutellaria baicalensis are originated from acid-neutralizing capacity, free radical scavenging effects and the antibacterial activity against Helicobacter pylori.
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KEYWORD
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baicalein, Scutellaria baicalensis, antigastritic, acid-neutralizing capacity, free radical scavenging effect, H. pylori
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